QualCann, S.A.S. is a Colombian-based fully licensed grower, extractor, and exporter of medical and food grade 100% natural hemp extracts that deliver unsurpassed quality in the hemp and cannabinoid industry. Our disciplined low-cost and high-quality approach to continuous improvement is perhaps unmatched in Colombia and in Latin America’s supply-chain.
We believe that cannabis has the power to change lives for the better, and we strive to make a positive difference through responsible business practices, community involvement, and philanthropic initiatives.
Guaranteed free of pathogens, heavy metals, and solvents, we hold ourselves and our products to higher standards of social responsibility within the communities we operate. All our oils are certified Kosher by OK
What makes us different
At QualCann we are more than just an innovative cannabis company. We are a team of experienced professionals who are dedicated to creating high-quality and pure cannabis products that meet the highest standards of excellence. But we don't stop at quality and excellence. We are also committed to making a positive social impact in the communities we serve. We believe that cannabis has the power to change lives for the better, and we strive to make a positive difference through responsible business practices, community involvement, and philanthropic initiatives.
From our commitment to sustainable and environmentally responsible practices, to our support for social justice and equity initiatives, we are always looking for ways to make a positive impact. Through our School Farms we give back by training and providing world-class genetics to small, medium and multigenerational farmers who know and love the plant, the land and the planet. Our best practices are currently empowering more than a dozen farmers and we will continue to spread the knowledge.
LUIS FERNANDO MARIA
Luis Fernando is a manager and administrator with over 20 years of experience, starting as a consultant for Arthur Andersen in the Business Consulting division and becoming the General Manager of Petrocorp S.A and General Manager of Trasco de Colombia S.A. He has been part of the board of directors of important public and private organizations in Colombia, was Secretary of Competitiveness and Economic Development of Cundinamarca and director of FTI Consulting Colombia. He has recently been the General Manager of Enaex Branch Colombia. Luis Fernando has a degree in Finance and International Relations from the Universidad Externado de Colombia, with postgraduate degrees in Finance and Business Law. He has been part of QualCann since its formation.
EDUARDO COVO MORALES
Research & Development Director
Eduardo has over 29 years of experience as a researcher and educator. He teaches undergraduates and postgraduates in the Health Campus of the University of Cartagena since 1994. He graduated as a Dentist with a specialty in Endodontics from the Pontificia Universidad Javeriana in Bogotá and holds a master’s degree in Microbiology from the medical school of the University of Cartagena, which has allowed him to participate in a number of scientific investigations related to basic sciences. He is an active member of diverse academic and scientific associations and has been published in peer-reviewed journals in multiple languages. Eduardo has been part of the company since its beginning.
RICARDO VIVAS REYES
Research and Investigation Methodology Advisor
Ricardo is an experienced researcher and chemist in the areas of chemical composition and pharmaceuticals. He obtained his bachelor and master’s degree from Universidad del Valle in Cali, Colombia and his Ph.D. from the Vrije Universiteit of Brussels. He is the author and co-author of over 100 publications in international peer-reviewed Journals including multiple book chapters. His fundamental work has been on the development of density functional theory-based descriptors of molecular charge distribution and reactivity (e.g., local hardness, shape function, (nuclear) Fukui functions, spin polarized extensions, linear response function) and on the development and testing related or testing related principles (the Hard and Soft Acids and Basis Concept, the Maximum Hardness Principle). In recent years, he has focused on applications in organic and inorganic chemistry, in catalysis, biochemistry, and medicinal chemistry. He has received multiple academic awards such as The National Chemistry Prize and The Prize for the Life and Work of a Chemist in Colombia, among many others. He is now dedicated to researching practical applications for cannabis extracts and promoting its evidence-based medicinal use and all other potentially unknown uses of cannabis phytochemicals.
Science We Respect
WHAT ARE CANNABINOIDS AND WHAT ARE THE BEST KNOWN?Cannabinoids are substances that come from the cannabis plant popularly called marijuana. There are three types of cannabinoids and they are classified according to their origin: those that come from the plant are called phytocannabinoids; those produced by our body called endocannabinoids; and those of synthetic origin. There is another method to define cannabinoids more technically and precisely. It is related to the fact that we have receptors in our body that interact with all 3 types of cannabinoids. With this in mind, we can define that a cannabinoid is a chemical substance, which regardless of its origin or structure, binds to specific receptors (CB1, CB2 and others). Endocannabinoids are distributed throughout the body, modulating neuro-immuno-endocrine activities and inducing effects similar to those produced by the plant. Among the most relevant phytocannabinoids, we can name: delta-9-trans-tetrahydrocannabinol (Δ9-THC), delta-8-tetrahydrocannabinol (Δ8-THC), cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN) and cannabitriol (CBT). 1. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. 2. Cannabis and neuroinflammation 3. Anandamide hydrolysis: a new target for anti-anxiety drugs? 4. Chemical Basis of Hashish Activity 5. History of cannabis as a medicine: a review 6. La marihuana con uso terapéutico en el contexto colombiano
CAN I BE DEPENDENT OR ADDICTED TO CANNABINOIDS?An important aspect to know is the fact that cannabinoids are not water-soluble but fat-soluble. This means that they are degraded more slowly at the liver compared to other substances such as opioids that are water-soluble. This means that its beneficial effects remain longer leading to less co-dependence. This claim is scientifically supported by studies that have demonstrated that cannabis is less addictive than other frequently used substances, such as nicotine, which has an addiction rate of 68%; heroin, which has a 23% rate, cocaine with a 17% rate, and alcohol with a 23% rate. Unlike these substances, cannabis is only responsible for 9% of those who smoke marijuana and refers only to THC, which is the cannabinoid present in recreational cannabis. The picture changes radically and the percentage drops to zero when it comes to other cannabinoids such as CBD or CBN, where there is no psychoactive effect; hence the importance of medical cannabis today. Links: 1. Marihuana Cannabis 2. Observational Safety Study of THC:CBD Oromucosal Spray (Sativex) in Multiple Sclerosis Patients with Spasticity
CAN YOU REALLY STOP TRADITIONAL PAIN MEDICATIONS AND REPLACE THEM WITH CBD?For the fans of singer Michael Jackson, it was painful to see their idol die from an overdose of opioids prescribed by his personal doctor. If in this particular case and many others, instead of providing an opioid-based treatment he had been given a cannabinoid-based one, perhaps he would still be among us. This is because cannabinoids do not have receptors in the brain stem from which certain functions such as respiratory and heart rate are governed. The advantage here of the use of cannabinoids is fundamental when you have severe pain prolonged over time (chronic pain). There are many people who depend in their daily lives on the use of painkillers as an inevitable fact bringing with it a whole series of undesirable side effects. For this reason, CBD-based medications are already beginning to replace a wide variety of conventional drugs in the treatment of common conditions, and may even be helpful for chronic pain. Some of the reasons for this replacement are because opiates pose a strong risk of addiction and physical dependence for the user and CBD does not. Over the past decade, researchers have discovered a complex and intricate relationship between endocannabinoid and opioid receptor systems. It is becoming apparent that opioid addiction and reward pathways in the brain and central nervous system, are also influenced by the activity of the endocannabinoid system. Additionally, cannabinoids can make opioids not only more effective, but also less harmful and less likely to cause consumer dependence. Links: 1. Understanding Cannabis-Based Therapeutics in Sports Medicine 2. Cannabinoids for Treatment of MS Symptoms: State of the Evidence 3. Re-branding cannabis: the next generation of chronic pain medicine? 4. Cannabis for Chronic Pain: Challenges and Considerations 5. Cannabis and Cannabinoids for Chronic Pain
CAN YOU OVERDOSE DUE TO THE USE OF CANNABINOIDS?A cannabinoid overdose is almost impossible unless an extraordinary dose is consumed. A death from cannabis overdose has never been documented as a direct cause of the event, demonstrating very clearly, the low toxicity of cannabinoids in general. Obviously, anyone who uses cannabis should have information about the possible side effects that can appear after its consumption. In the case of CBD, there is no record of adverse effects due to high doses, however, high doses tend to be less effective therapeutically. Links: 1. Chemistry of Cannabis 2. Chemistry of marihuana
WHAT IS THE ENDOCANNABINOID SYSTEM?In the 60s, R. Mechoulam discovered the endocannabinoid system. Questions arose concerning the reason of its existence and why that system had more receptors than any other in the human body. Professor Mechoulam found that the human body produced its own cannabinoids, focusing mainly on arachidonylethanolamide or anandamide and 2-arachidonoylglycerol (2-AG). Two types of receptors have been described for endogenous cannabinoids: CB1, located mostly in the brain, and CB2, located throughout the immune system. Anandamide and 2-AG most likely act as neurotransmitters or neuromodulators; they also act as signaling molecules and therefore help maintain balance in many bodily processes. Endogenous cannabinoids are lipid molecules capable of mimicking the effects produced by Δ9-tetrahydrocannabinol and cannabinol (CBD); they are derivatives of the arachidonic acid and participate in numerous body processes. The distribution in the brain of the endocannabinoids and the CB1 receptors, have allowed us to know the physiological functions in which this system is involved. Links: 1. Endocannabinoids 2. Endocannabinoids and Cancer 3. Endocannabinoids as Therapeutic Targets 4. Endocannabinoids and Their Pharmacological Actions
WHAT IS THE CBN? PROPERTIES AND USESCBN (cannabinol) is a cannabinoid found in cannabis plants, and it is one of the many compounds that interact with the endocannabinoid system (ECS) in the body. The ECS is a complex biological system that plays a role in regulating a range of physiological processes, including pain, mood, appetite, and sleep. CBN works by binding to cannabinoid receptors in the body, specifically the CB1 and CB2 receptors. CB1 receptors are primarily found in the brain and nervous system, while CB2 receptors are found throughout the body, including in the immune system. When CBN binds to these receptors, it can have a range of effects, including reducing pain, promoting relaxation, and helping to regulate sleep. CBN is also thought to have a mild psychoactive effect, although it is not as potent as THC (tetrahydrocannabinol), the primary psychoactive compound in cannabis. Some research suggests that CBN may have anti-inflammatory and antibacterial properties, although more research is needed to fully understand its potential benefits. 1. Cannabinol: History, Syntheses, and Biological Profile of the Greatest “Minor” Cannabinoid. 2. Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain. 3. Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research.
MY PET CAN USE CANNABINOIDS?The use of cannabinoids in dogs and cats is recent. Studies show that healthy animals tolerate doses of 2 mg/kg body weight of CBD with terpenes for more than twelve weeks non-stop. Investigations show that cannabinoid use does not result in clinically significant alterations in the hematology or biochemistry of the animals in the trial. There were only alterations in a single case of a cat, which showed a persistent increase in serum alanine aminotransferase (ALT) during the course of the study. Medical cannabis rich in CBD and CBDA appear to be safe in healthy adult dogs, while in cats additional work is needed to fully understand their use and absorption. Trials show that the safe dose for a good clinical start for most animals is 1 mg/kg body weight twice daily to ensure good adsorption. Some articles claim that CBD for dogs is effective in decreasing anxiety. Others, however, find it dubious because since CBD is non-psychoactive, it is unlikely to have the ability to directly treat canine anxiety the way other anxiolytic medications do. This dose is safe and effective for the conditions studied (arthritis and seizures), but additional research is still needed to evaluate the doses of CBD needed in the treatment of other conditions. There is no scientific data on the side effects of CBD use in dogs, but they could exist based on how CBD affects humans. To minimize possible side effects, it is important to ensure the right dose for our pet individually. Links: 1. Single-Dose Pharmacokinetics and Preliminary Safety Assessment with Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats 2. Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste 3. Cannabinoids, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements Vet Med (Auckl) 15 de abril de 2020 (11) 45-55 4. Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
CAN D9-THC BE USED IN MEDICAL APPLICATIONS?There is extensive literature regarding the most well-known and controversial cannabinoid: THC. THC is popularly associated with its recreational and hallucinogenic effects. Recently, part of that story has changed drastically to find that it has medicinal properties that help effectively and accurately in the treatment of certain pathologies. Chemical and clinical studies on Delta-9 since the 70s, have demonstrated the effectiveness of this molecule to inhibit tumor growth in laboratory models. Additionally, it has been used successfully as an antiemetic, anxiolytic, appetite stimulant, analgesic, neuro-protection, management of neuropathic pain and other conditions. 1. Action of cannabidiol on the anxiety and other effects produced by delta-9-THC in normal subjects. 2. Cannabidiol: an overview of some chemical and pharmacological aspects
Here you have easily accessible and reliable scientific information about hemp and cannabinoids. There are two sections: one with a biweekly blog where we will share interesting and new related topics and a second section with curated links organized by topics of interest from prestigious journals around the world.